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Doxycycline


Doxycycline is a member of the tetracycline antibiotics group and is commonly used to treat various infections. Doxycycline is a semisynthetic tetracycline invented and clinically developed in the early 1960s, the company Pfizer Inc and marketed under the name Vibramycin.
Vibramycin received U.S. Food and Drug Administration approval in 1967. Other brands include Monodox, Microdox, Periostat, Vibra-Tabs, Oracea, Doryx, Vibrox, Adoxa, Doxyhexal, Doxylin, Doxoral, Doxy-1 and Atridox (actual Hyclate doxycycline for periodontitis).
It is used in prophylaxis against malaria. It should only be used for the initial treatment of malaria, even when the parasite is doxycycline-sensitive, because the antimalarial effect of doxycycline delayed.
This delay is related to its mechanism of action that specifically impair the progeny of apicoplast genes resulting in their abnormal cell division. It can be used in the treatment plan in combination with other agents such as quinine